Hypersomatotropism (Acromegaly) is a medium-severity endocrine condition that can affect dogs of all ages and breeds. Canine acromegaly is caused by excess growth hormone, most commonly from progesterone-stimulated mammary GH production in intact bitches. It causes soft tissue overgrowth, insulin-resistant diabetes, and cardiomyopathy. It is documented across 1 breed, though prevalence and severity can differ significantly between them. It typically becomes apparent at 7-10 years. Early signs to watch for include broadening of facial features, increased skin folds, enlarged abdomen, and inspiratory stridor. When treatment is required, costs are estimated at £500-£2,500 depending on severity, location, and the specific intervention needed. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.

Signs & Symptoms

The following symptoms are commonly associated with Hypersomatotropism (Acromegaly) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.

• Broadening of facial features
• Increased skin folds
• Enlarged abdomen
• Inspiratory stridor
• Diabetes mellitus resistant to insulin
• Weight gain

Treatment Overview

Ovariohysterectomy is curative in progesterone-dependent cases (most common). Pituitary-dependent forms are treated with cabergoline or pasireotide, or pituitary irradiation if available.

Typical onset: 7-10 years

Prevention & Screening

While not all cases of Hypersomatotropism (Acromegaly) can be prevented, the following steps reduce risk or enable earlier intervention:

• Spaying intact bitches eliminates the most common trigger
• Avoid progesterone-based medications