Addison's Disease (Hypoadrenocorticism) in Dogs
Addison's Disease (Hypoadrenocorticism) is a high-severity endocrine condition that can affect dogs of all ages and breeds. Addison's disease is caused by destruction of the adrenal cortex, leading to deficiency of glucocorticoids and mineralocorticoids. It can present as acute life-threatening 'Addisonian crisis' or with vague chronic signs that mimic many other conditions. It is documented across 5 breeds, though prevalence and severity can differ significantly between them. It typically becomes apparent at 4-7 years. Early signs to watch for include lethargy and weakness, vomiting and diarrhoea, shaking, and collapse (addisonian crisis). When treatment is required, costs are estimated at £800-£2,500/year depending on severity, location, and the specific intervention needed. Addison's Disease (Hypoadrenocorticism) has a hereditary component, so health-screening certificates from the breeder are strongly recommended for predisposed breeds. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.
Signs & Symptoms
The following symptoms are commonly associated with Addison's Disease (Hypoadrenocorticism) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.
- Lethargy and weakness
- Vomiting and diarrhoea
- Shaking
- Collapse (Addisonian crisis)
- Weight loss
- Increased thirst
Treatment Overview
Acute crisis requires emergency IV fluids, dextrose, and corticosteroids. Maintenance involves lifelong monthly DOCP injections (mineralocorticoid) and daily prednisolone (glucocorticoid).
Typical onset: 4-7 years
Prevention & Screening
While not all cases of Addison's Disease (Hypoadrenocorticism) can be prevented, the following steps reduce risk or enable earlier intervention:
- No proven prevention
- Genetic research ongoing for some breeds
Estimated Treatment Cost
Treatment for Addison's Disease (Hypoadrenocorticism) is estimated at £800-£2,500/year, depending on severity, the specific intervention required, and your location. Costs may be higher for surgical procedures or ongoing management. Comprehensive pet insurance covering hereditary conditions is strongly recommended.
Breeds Affected by Addison's Disease (Hypoadrenocorticism)
The following 7 breeds are documented as being susceptible to Addison's Disease (Hypoadrenocorticism). Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.
Looking for more information? Browse all dog health conditions or explore the health guides for in-depth breed care advice.