Cushing's Disease (Hyperadrenocorticism) in Dogs
Cushing's Disease (Hyperadrenocorticism) is a medium-severity endocrine condition that can affect dogs of all ages and breeds. Cushing's disease results from excess cortisol, most commonly from a pituitary adenoma (PDH) or, less often, an adrenal tumour (AT). The chronic cortisol excess causes characteristic physical and metabolic changes. It is documented across 6 breeds, though prevalence and severity can differ significantly between them. It typically becomes apparent at 7-12 years. Early signs to watch for include pot-bellied appearance, increased thirst and urination, increased appetite, and bilateral hair loss. When treatment is required, costs are estimated at £1,000-£3,000/year depending on severity, location, and the specific intervention needed. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.
Signs & Symptoms
The following symptoms are commonly associated with Cushing's Disease (Hyperadrenocorticism) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.
- Pot-bellied appearance
- Increased thirst and urination
- Increased appetite
- Bilateral hair loss
- Thin skin with bruising
- Lethargy
Treatment Overview
PDH is treated medically with trilostane or mitotane, requiring regular monitoring. Adrenal tumours may be surgically removed. Treatment is lifelong and significantly improves quality of life.
Typical onset: 7-12 years
Prevention & Screening
While not all cases of Cushing's Disease (Hyperadrenocorticism) can be prevented, the following steps reduce risk or enable earlier intervention:
- No proven prevention
- Avoid prolonged unnecessary steroid medication
Estimated Treatment Cost
Treatment for Cushing's Disease (Hyperadrenocorticism) is estimated at £1,000-£3,000/year, depending on severity, the specific intervention required, and your location. Costs may be higher for surgical procedures or ongoing management. Comprehensive pet insurance covering this condition is strongly recommended.
Breeds Affected by Cushing's Disease (Hyperadrenocorticism)
The following 5 breeds are documented as being susceptible to Cushing's Disease (Hyperadrenocorticism). Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.
Looking for more information? Browse all dog health conditions or explore the health guides for in-depth breed care advice.