Degenerative Myelopathy (DM) in Dogs
Degenerative Myelopathy (DM) is a high-severity neurological condition that can affect dogs of all ages and breeds. DM is a progressive, non-painful spinal cord disease caused by a mutation in the SOD1 gene. It begins with hind limb weakness and ataxia, progressing to complete paralysis and eventually fore limb involvement. It is analogous to ALS in humans. It is documented across 6 breeds, though prevalence and severity can differ significantly between them. It typically becomes apparent at 8-14 years. Early signs to watch for include progressive hind limb weakness, knuckling of hind paws, dragging hind legs, and loss of bladder and bowel control. When treatment is required, costs are estimated at £500-£3,000/year depending on severity, location, and the specific intervention needed. Degenerative Myelopathy (DM) has a hereditary component, so health-screening certificates from the breeder are strongly recommended for predisposed breeds. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.
Signs & Symptoms
The following symptoms are commonly associated with Degenerative Myelopathy (DM) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.
- Progressive hind limb weakness
- Knuckling of hind paws
- Dragging hind legs
- Loss of bladder and bowel control
- Loss of muscle mass
Treatment Overview
There is no cure or disease-modifying treatment. Intensive physiotherapy and hydrotherapy can slow decline and maintain quality of life. Wheelchairs improve mobility in later stages.
Typical onset: 8-14 years
Prevention & Screening
While not all cases of Degenerative Myelopathy (DM) can be prevented, the following steps reduce risk or enable earlier intervention:
- DNA test available (OFA) — avoid breeding at-risk (AT/AT) pairings
- Test all breeding stock
Estimated Treatment Cost
Treatment for Degenerative Myelopathy (DM) is estimated at £500-£3,000/year, depending on severity, the specific intervention required, and your location. Costs may be higher for surgical procedures or ongoing management. Comprehensive pet insurance covering hereditary conditions is strongly recommended.
Breeds Affected by Degenerative Myelopathy (DM)
The following 8 breeds are documented as being susceptible to Degenerative Myelopathy (DM). Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.
Looking for more information? Browse all dog health conditions or explore the health guides for in-depth breed care advice.