Hereditary Nasal Parakeratosis (HNPK) is a low-severity dermatological condition that can affect dogs of all ages and breeds. HNPK is a hereditary condition in Labrador Retrievers causing thickening, crusting, and fissuring of the nasal planum from a young age. The nose becomes grey, crusty, and painful with fissures that can become infected. It is documented across 1 breed, though prevalence and severity can differ significantly between them. It typically becomes apparent at 6 months - 1 year. Early signs to watch for include thickened grey crusting of nose, nose fissuring and cracking, secondary bacterial infection of nose, and bleeding from nasal fissures. When treatment is required, costs are estimated at £100-£400/year depending on severity, location, and the specific intervention needed. Hereditary Nasal Parakeratosis (HNPK) has a hereditary component, so health-screening certificates from the breeder are strongly recommended for predisposed breeds. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.

Signs & Symptoms

The following symptoms are commonly associated with Hereditary Nasal Parakeratosis (HNPK) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.

• Thickened grey crusting of nose
• Nose fissuring and cracking
• Secondary bacterial infection of nose
• Bleeding from nasal fissures
• Discomfort when touching nose

Treatment Overview

There is no cure. Regular moisturising with petroleum jelly or specific nasal balms manages the condition. Antibiotic treatment for secondary infections when needed. Lifelong management is required.

Typical onset: 6 months - 1 year

Prevention & Screening

While not all cases of Hereditary Nasal Parakeratosis (HNPK) can be prevented, the following steps reduce risk or enable earlier intervention:

• DNA test available (SUV39H2 mutation)
• Test all breeding Labradors — avoid affected-to-affected matings

Breeds Affected by Hereditary Nasal Parakeratosis (HNPK)

The following 1 breed are documented as being susceptible to Hereditary Nasal Parakeratosis (HNPK). Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.

• Labrador Retriever (large)