Insulinoma is a high-severity endocrine condition that can affect dogs of all ages and breeds. Insulinoma is a tumour of the insulin-producing beta cells of the pancreas that secretes excess insulin, causing persistent hypoglycaemia. Episodes of weakness, collapse, and seizures result from the brain being starved of glucose. It is documented across 5 breeds, though prevalence and severity can differ significantly between them. It typically becomes apparent at 8-12 years. Early signs to watch for include weakness and wobbliness, collapse, seizures, and glazed expression. When treatment is required, costs are estimated at £3,000-£7,000 depending on severity, location, and the specific intervention needed. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.

Signs & Symptoms

The following symptoms are commonly associated with Insulinoma in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.

• Weakness and wobbliness
• Collapse
• Seizures
• Glazed expression
• Rapid improvement after eating sugar

Treatment Overview

Surgical removal of visible tumours is the treatment of choice. Medical management with frequent small meals, prednisolone, and diazoxide helps stabilise blood glucose. Prognosis is guarded due to malignancy risk.

Typical onset: 8-12 years

Prevention & Screening

While not all cases of Insulinoma can be prevented, the following steps reduce risk or enable earlier intervention:

• No proven prevention
• Prompt investigation of unexplained hypoglycaemia

Breeds Affected by Insulinoma

The following 4 breeds are documented as being susceptible to Insulinoma. Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.

• Irish Setter (large)
• Labrador Retriever (large)
• German Shepherd (large)
• Boxer (large)