Systemic Lupus Erythematosus (SLE) in Dogs
Systemic Lupus Erythematosus (SLE) is a high-severity autoimmune condition that can affect dogs of all ages and breeds. SLE is a complex immune-mediated disease characterised by autoantibody production against multiple tissues, causing a wide variety of signs including polyarthritis, skin lesions, haematological abnormalities, and kidney disease. It is documented across 5 breeds, though prevalence and severity can differ significantly between them. It typically becomes apparent at 2-8 years. Early signs to watch for include shifting lameness (polyarthritis), skin ulceration and hair loss, fever, and anaemia. When treatment is required, costs are estimated at £2,000-£6,000/year depending on severity, location, and the specific intervention needed. This page covers symptoms, treatment options, and preventive steps — along with breed-specific information where available.
Signs & Symptoms
The following symptoms are commonly associated with Systemic Lupus Erythematosus (SLE) in dogs. If your dog displays several of these signs, consult your vet promptly — early diagnosis typically leads to better outcomes.
- Shifting lameness (polyarthritis)
- Skin ulceration and hair loss
- Fever
- Anaemia
- Proteinuria
- Lymphadenopathy
Treatment Overview
Immunosuppressive therapy with prednisolone, often combined with azathioprine or other immunosuppressants, is the foundation of treatment. Management is lifelong and complex with a guarded prognosis.
Typical onset: 2-8 years
Prevention & Screening
While not all cases of Systemic Lupus Erythematosus (SLE) can be prevented, the following steps reduce risk or enable earlier intervention:
- No proven prevention
- Avoid unnecessary drug exposure
Estimated Treatment Cost
Treatment for Systemic Lupus Erythematosus (SLE) is estimated at £2,000-£6,000/year, depending on severity, the specific intervention required, and your location. Costs may be higher for surgical procedures or ongoing management. Comprehensive pet insurance covering this condition is strongly recommended.
Breeds Affected by Systemic Lupus Erythematosus (SLE)
The following 5 breeds are documented as being susceptible to Systemic Lupus Erythematosus (SLE). Click any breed to view breed-specific information about this condition, including prevalence and recommended screening.
Looking for more information? Browse all dog health conditions or explore the health guides for in-depth breed care advice.